Arthritis Research UK Medical Research Council

CIMA Cohorts

This page comprises a list of available cohorts (tissue, preclinical, clinical and population samples) within CIMA and external cohorts of interest for Musculoskeletal Ageing Research.

This page comprises a list of available cohorts (tissue, preclinical, clinical and population samples) within CIMA and external cohorts of interest for Musculoskeletal Ageing Research.

CIMA is committed to sharing existing resources with researchers across the Centre and also with collaborators from outside CIMA. Much time, effort and expenditure has established the individual cohorts listed below. Each cohort is described briefly with a link to the website (if available) and a point of contact for requests for collaboration.

Clinical Cohorts

Carcinoid Study

Men and women age 18y or older with carcinoid syndrome n=60 DXA, serum samples

J Walsh (j.walsh@sheffield.ac.uk)

DO-HEALTH

DO-HEALTH is a 3-year clinical trial designed to support healthy aging in European seniors and to establish whether vitamin D, omega-3 fatty acids, and a simple home exercise program will prevent disease at older age and thereby prolong healthy life expectancy. It has enrolled 2152 community-dwelling men and women who are 70 years and older, an age when chronic diseases increase substantially.

asa-mueller@do-health.eu

Halcyon Cohorts

Together, the HALCyon cohorts cover 30,000 individuals born between 1918 and 1958, and aged 50 years or older at the start of the programme in 2008. These cohorts were chosen because they already have rich biosocial data that were used in the HALCyon work packages. Seven of the nine cohorts are life course studies with data from childhood and adulthood. The other two are adult cohorts (ELSA and Caerphilly) were included because of rich and repeated data in adult life. All the cohorts have data on adult physical or cognitive capability; Lothian, Caerphilly and NSHD have repeat measures. All have measures of self-reported functioning, wellbeing and mental health, lifetime social conditions, adult lifestyle and DNA, tests and serum markers of cardiovascular and other biological function, and stored blood samples. Five (HAS, HCS, Boyd Orr, NSHD and NCDS) have measures of infant and/or childhood growth and four (Lothian, Aberdeen, NSHD and NCDS) have measures of childhood cognitive function. Two (NSHD and Boyd Orr) have data on childhood diet.

Metal Ions Study

72 patients, 36 who are 9 years post MOMHR, and 36 age sex matched controls 9 years after conventional THA. DXA, cardiac ECHO, whole blood, serum, urine, brain MRI, complete haematology, biochemistry, ophthalmology, audiology

Prof Mark Wilkinson (j.m.wilkinson@sheffield.ac.uk)

MRC Hip Fracture Study

A 4 year prospective study of 5212 women aged 75+ with mutiple baseline measures of musculoskeletal health and quality of life. Incident events include fractures (adjudicated), mortality and many other outcomes captured as SAEs.

Prof Eugene McCloskey (e.v.mccloskey@sheffield.ac.uk)

Newcastle 85+ Cohort

The 85+ Study aimed to: assess the spectrum of health in the oldest old; examine the associations of health trajectories and outcomes with biological, clinical and social factors as the cohort ages; identify factors which contribute to the maintenance of health and independence; advance understanding of the biological nature of human ageing

Professor Tom Kirkwood (Tom.kirkwood@newcastle.ac.uk)

NJR Developmental Dysplasia of the Hip (DDH) Biobank

900 subjects DNA with a diagnosis of DDH who have had a total hip arthroplasty, plus clinical and family history data

Prof Mark Wilkinson (j.m.wilkinson@sheffield.ac.uk)

Norwegian hip osteoarthritis (OA) cohort

4,000 Norwegian subjects DNA with a diagnosis of OA and had total hip arthroplasty, plus clinical outcomes data.

Prof Mark Wilkinson (j.m.wilkinson@sheffield.ac.uk)

Oestradiol and Vertebral Frcture

Observatonal cross-sectional study of postmenopausal women with vertebral fracture and BMD matched controls n=100, DXA, VFA, HRpQCT, serum, urine, plasma

R Eastell (r.eastell@sheffield.ac.uk)

Osteoporosis and Ultrasound (OPUS)

European multicentre population based study of postmenopausal women (55 to 79y) and premenopausal women (20 to 39y), n=2837. Procedures include QUS, DXA/MXA, spine x-rays, Questionnaire, Samples: seum, urine, DNA

Richard Eastell (r.eastell@sheffield.ac.uk)

Peak Bone Mass

Healthy male and female subjects n=116 DXA, serum, urine

J Walsh (j.walsh@sheffield.ac.uk)

Reference range

Healthy premenopausal women age 30 to 45y n=200, serum and urine

R Eastell (r.eastell@sheffield.ac.uk)

SCOOP Study

The SCOOP randomised controlled trial is a study designed to test a method of screening for risk of fracture for women aged 70 to 85 years. Women in this age group recruited to the study will either be screened or managed as usual. Those screened and considered at high risk will be offered treatment by their GPs. The study will consist of 5 years follow-up and it is hoped that screening will reduce the number of fractures by around 25%. Funding for the study has been secured from the Medical Research Council and Arthritis Research UK and it has been endorsed by the National Osteoporosis Society. The study is co-ordinated by the University of East Anglia.

Chief Investigator: Prof Lee Shepstone, University of East Anglia (L.Shepstone@uea.ac.uk). Sheffield PI Prof Eugene McCloskey (e.v.mccloskey@sheffield.ac.uk)

South Yorkshire Cohort

The South Yorkshire Cohort is a research project that will follow the lives of 20,000 adults in South Yorkshire over the next 10 years. It will provide up to date information on changes in the health of people in South Yorkshire, tell us how adults in South Yorkshire use the NHS and other healthcare resources and provide researchers with a way to research health.

Principal Investigator: Prof Liddy Goyder, Deputy Dean, Section of Public Health, ScHARR, University of Sheffield (e.goyder@sheffield.ac.uk)

Stem Design Study

120 subjects in 3 prosthesis, 2 year RCT of influence of cemented femoral component design on proximal femoral bone remodelling. Clinical, plain radiographic, DXA, biomarker data

Prof Mark Wilkinson (j.m.wilkinson@sheffield.ac.uk)

The effects of obesity on bone sucture and strength

Men and women n=240 BMI betwen 18.5 and 24.9kg/m2 or greater than 30kg/m2. DXA, bone strength, serum, urine, plasma samples

J Walsh (j.walsh@sheffield.ac.uk)

UK MYONET

This is an ongoing UK national collaboration recruiting adult patients with idiopathic inflammatory myopathies (IIM), i.e polymyositis, dermatomyositis and inclusion body myositis. Recruitment is ongoing in ~ 70 UK centres, and we have to date recruited >1400 IIM patients, with their plasma, serum, DNA and clinical phenotype details stored in the Centre for Integrated Medical Genomic Research (CIGMR) in the University of Manchester. This cohort is supporting ongoing genetic and serological research aimed at improving diagnosis and management of these rare and difficult diseases. There is also a tissue bank from which samples can be requested in writing.

Prof Robert Cooper (Robert.Cooper@liverpool.ac.uk)

XtremeCT study

Populaton based male and female volunteers age 16-18y, 30-32y >69y n=180, serum samples

J Walsh (j.walsh@sheffield.ac.uk)

Preclinical Cohorts

Preclinical Cohorts

Shared Ageing Research Models (ShARM)

ShARM is a not for profit organisation, open to all scientific investigators in the UK and overseas, aiming to accelerate research into ageing by facilitating the sharing of resources. ShARM provides immediate and cost effective access to aged murine models and their tissue through a biorepository and database of live ageing colonies. ShARM also promotes the networking of researchers and dissemination of knowledge through its online collaborative environment; MICEspace.

Via the website

Biobanks

No Biobanks Cohorts