Arthritis Research UK Medical Research Council

CIMA Profiles

CIMA is led by the Centre Director, Prof Malcolm Jackson, in collaboration with Site Directors Prof Eugene McCloskey and Prof John Loughlin. To view the profiles of our Directors, Co-Investigators, Research Collaborators and Students at each site, please click on the colour University logos at the bottom of this page.


Directors

Professor Malcolm Jackson

Professor Malcolm Jackson

University of Liverpool

Professor Jackson graduated with a BSc in Biochemistry from the University of Surrey in 1974, completed a PhD at University College London in 1980, was awarded a DSc in 1994 and FRCPath in 1997. He was a Lecturer at University College London in 1982, Senior Lecturer at Liverpool University in 1984 and appointed Professor in 1994. He has served as Head of the Department of Medicine (1997-2001), Deputy Dean (2000-2001), Interim Dean of the Faculty of Medicine (2001-2002) and Associate Dean for Research (2005-2009). He was appointed Head of the Institute of Ageing and Chronic Disease in 2010. Malcolm serves on the MRC Population and Systems Medicine Board and Interdisciplinary Expert Group on ME/CFS, the BBSRC Healthy Organism Strategy Panel and Ageing Working Group and the Joint Research Councils Life Long Health and Wellbeing Panel. He was Deputy Chair of the Research into Ageing National Scientific Advisory Committee (2003-2006) and is current President of the Society for Free Radical Research-International.

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Professor Eugene McCloskey

Professor Eugene McCloskey

The University of Sheffield

Professor McCloskey graduated in Medicine from Trinity College, Dublin in 1983. Having initially trained in endocrinology, he developed an interest in the mechanisms of malignant bone disease and has been involved in several clinical trials of bisphosphonates in multiple myeloma and breast cancer that have established the role of antiosteoclastic therapy in malignant disease. He subsequently trained in rheumatology before deciding to focus exclusively on metabolic bone diseases. Currently, Professor in Adult Bone Diseases in the Academic Unit of Bone Metabolism, he is also an Honorary Consultant Physician in metabolic bone disease at the Northern General Hospital, Sheffield. He has published over 150 peerreviewed articles, book chapters and reviews and is currently Secretary of the Bone Research Society, Chair of the ASBMR Ancillary Program Committee and Chair of the National Osteoporosis Guideline Group Implementation Committee as well as a member of the ARUK Research sub-committee, the National Specialty Group for Musculoskeletal Diseases, the International Osteoporosis Foundation’s Committee of Scientific Advisors and the Board of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis.

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Professor John Loughlin

Professor John Loughlin

Newcastle University

Professor Loughlin is a molecular and cell biologist with a background in genetics. He did his PhD in developmental biology at Leeds University and his postdoctoral studies at the Institute of Molecular Medicine at Oxford University. These involved a molecular genetic analysis of diseases of the musculoskeletal system. He subsequently obtained a fellowship from the Arthritis Research Campaign and established a group at the Wellcome Trust Centre for Human Genetics. At that point his focus became the genetic analysis of osteoarthritis (OA). In 2002 he was awarded a tenured lectureship at Oxford and in 2008 he moved to Newcastle as Professor of Musculoskeletal Research.
Professor Loughlin’s laboratory focuses on the identification and characterization of those genes that confer risk towards the development and progression of osteoarthritis (OA). Through the application of powerful genome-wide association scans involving tens of thousands of OA patients his group has identified a large number of OA susceptibility genes, including CHST11, GDF5, DIO2 and HBP1. His group’s efforts are directed toward comprehensive functional analysis of the associated variants within these genes, and in others that are emerging from ongoing scans.
From 2007-2011 he was the principal investigator for arcOGEN, a UK consortium funded by Arthritis Research UK and directed toward the association mapping of OA susceptibility loci. The consortium involved multiple centers across the UK and helped to delineate the genetic architecture of this common disease.
Professor Loughlin is the President-elect of the Osteoarthritis Research Society International (OARSI), which is the major international OA research society, and he has published peer reviewed papers in a number of leading journals including Nature Genetics, PNAS, The Lancet, BMJ, American Journal of Human Genetics, PLoS Genetics, Human Molecular Genetics, Journal of Biological Chemistry and Arthritis & Rheumatism.

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