Arthritis Research UK Medical Research Council

CIMA Cohorts

CIMA is committed to sharing existing resources with researchers across the Centre and also with collaborators from outside CIMA. Each cohort is described with a link to its website (if available) and a point of contact for requests for collaboration.

 

Cohort

Details

Contact

Carcinoid study
(Clinical)

60 men and women aged 18 years or older with carcinoid syndrome

DXA, serum samples

Dr Jennifer Walsh

Clinical Senior Lecturer

j.walsh@sheffield.ac.uk

DO-HEALTH
(Clinical)

DO-HEALTH is a 3-year clinical trial designed to support healthy aging in European seniors and to establish whether vitamin D, omega-3 fatty acids, and a simple home exercise program will prevent disease at older age and thereby prolong healthy life expectancy. It has enrolled 2,152 community-dwelling men and women who are aged 70 years and older, an age when chronic diseases increase substantially.

Dr. Åsa Müller-Grunditz

DO-HEALTH Manager and Research Associate

asa-mueller@do-health.eu

Halcyon Cohorts
(Clinical)

Together, the HALCyon cohorts cover 30,000 individuals born between 1918 and 1958, and aged 50 years or older at the start of the programme in 2008. These cohorts were chosen because they already have rich biosocial data that were used in the HALCyon work packages.

Dr Stephanie Pilling

Project Co-ordinator

stephanie.pilling@ucl.ac.uk

Metal Ions Study
(Clinical)

72 patients, 36 who are 9 years post MOMHR

36 age-sex-matched controls 9 years after conventional THA

DXA, cardiac ECHO, whole blood, serum, urine, brain MRI, complete haematology, biochemistry, ophthalmology, audiology

Professor Mark Wilkinson

Professor of Orthopaedics

j.m.wilkinson@sheffield.ac.uk

MRC Hip Fracture Study
(Clinical)

A four-year prospective study of 5,212 women aged 75+ with multiple baseline measures of musculoskeletal health and quality of life. Incident events include fractures (adjudicated), mortality and many other outcomes captured as serious adverse events (SAEs).

Professor Eugene McCloskey

Professor in Adult Bone Disease

e.v.mccloskey@sheffield.ac.uk

Newcastle 85+ cohort
(Clinical)

The 85+ Study aimed to:

  • assess the spectrum of health in the oldest old
  • examine the associations of health trajectories and outcomes with biological, clinical and social factors as the cohort ages
  • identify factors which contribute to the maintenance of health and independence
  • advance understanding of the biological nature of human ageing

Professor Tom Kirkwood

Associate Dean for Ageing

tom.kirkwood@ncl.ac.uk

National Joint Registry (NJR) Developmental Dysplasia of the Hip (DDH) Biobank
(Clinical)

900 subjects DNA with a diagnosis of DDH who have had a total hip arthroplasty, plus clinical and family history data

Professor Mark Wilkinson

Professor of Orthopaedics

j.m.wilkinson@sheffield.ac.uk

Norwegian hip osteoarthritis (OA) cohort
(Clinical)

4,000 Norwegian subjects DNA with a diagnosis of OA and had total hip arthroplasty, plus clinical outcomes data.

Professor Mark Wilkinson

Professor of Orthopaedics

j.m.wilkinson@sheffield.ac.uk

Oestradiol and Vertebral Fracture
(Clinical)

Observational cross-sectional study of 100 post-menopausal women with vertebral fracture and BMD matched control

DXA, VFA, HRpQCT, serum, urine, plasma

Professor Richard Eastell

Professor and Head of the Academic Unit of Bone Metabolism

Director of the Mellanby Centre for Bone Research

r.eastell@sheffield.ac.uk

Osteoporosis and Ultrasound (OPUS)
(Clinical)

European multicentre population based study of 2,837 postmenopausal women (aged 55 to 79) and premenopausal women (aged 20 to 39)

Procedures: QUS, DXA/MXA, spine x-rays, questionnaire

Samples: serum, urine, DNA

Professor Richard Eastell

Professor and Head of the Academic Unit of Bone Metabolism

Director of the Mellanby Centre for Bone Research

r.eastell@sheffield.ac.uk

Peak Bone Mass
(Clinical)

116 healthy male and female subjects

DXA, serum, urine

Dr Jennifer Walsh

Clinical Senior Lecturer

j.walsh@sheffield.ac.uk

Reference range
(Clinical)

200 healthy premenopausal women aged 30 to 45

Serum and urine

Professor Richard Eastell

Professor and Head of the Academic Unit of Bone Metabolism

Director of the Mellanby Centre for Bone Research

r.eastell@sheffield.ac.uk

SCOOP study
(Clinical)

The SCOOP randomised controlled trial is a study designed to test a method of screening for risk of fracture for women aged 70 to 85 years. Women in this age group recruited to the study were either screened or managed as usual. Those screened and considered at high risk were offered treatment by their GPs. The study consists of 5 years follow-up and it is hoped that screening will reduce the number of fractures by around 25%.

Funding: Medical Research Council and Arthritis Research UK

Endorsed: National Osteoporosis Society.

Co-ordination: University of East Anglia

Professor Lee Shepstone

Professor of Medical Statistics

l.shepstone@uea.ac.uk

 

Professor Eugene McCloskey

Professor in Adult Bone Disease

e.v.mccloskey@sheffield.ac.uk

Shared Ageing Research Models (ShARM)
(Pre-clinical)
ShARM is a not for profit organisation, open to all scientific investigators in the UK and overseas, aiming to accelerate research into ageing by facilitating the sharing of resources. ShARM provides immediate and cost effective access to aged murine models and their tissue through a biorepository and database of live ageing colonies. ShARM also promotes the networking of researchers and dissemination of knowledge through its online collaborative environment; MICEspace.  Contact via the website 

South Yorkshire Cohort
(Clinical)

The South Yorkshire Cohort is a research project that is following the lives of 20,000 adults in South Yorkshire over 10 years. It will provide up to date information on changes in the health of people in South Yorkshire, tell us how adults in South Yorkshire use the NHS and other healthcare resources and provide researchers with a way to research health.

Professor Liddy Goyder

Deputy Dean, Section of Public Health, ScHARR, University of Sheffield

e.goyder@sheffield.ac.uk

Stem Design Study
(Clinical)

120 subjects in 3 prosthesis

2 year RCT of influence of cemented femoral component design on proximal femoral bone remodelling.

Clinical, plain radiographic, DXA, biomarker data

Professor Mark Wilkinson

Professor of Orthopaedics

j.m.wilkinson@sheffield.ac.uk

The effects of obesity on bone structure and strength
(Clinical)

240 men and women

BMI between 18.5 and 24.9kg/m2 or greater than 30kg/m2.

DXA, bone strength, serum, urine, plasma samples

Dr Jennifer Walsh

Clinical Senior Lecturer

j.walsh@sheffield.ac.uk

UK MYONET
(Clinical)

This is an ongoing UK national collaboration recruiting adult patients with idiopathic inflammatory myopathies (IIM), i.e polymyositis, dermatomyositis and inclusion body myositis. Recruitment has taken place in ~70 UK centres, and we have so far recruited >1400 IIM patients, with their plasma, serum, DNA and clinical phenotype details stored in the Centre for Integrated Medical Genomic Research (CIGMR) in the University of Manchester. This cohort is supporting ongoing genetic and serological research aimed at improving diagnosis and management of these rare and difficult diseases. There is also a tissue bank from which samples can be requested in writing.

Professor Robert Cooper

Professor of Experimental Medicine

robert.cooper@liverpool.ac.uk

 

XtremeCT study
(Clinical)

Population-based male and female volunteers

aged 16-18, 30-32 and >69y

n=180

Serum samples

Dr Jennifer Walsh

Clinical Senior Lecturer

j.walsh@sheffield.ac.uk