Arthritis Research UK Medical Research Council

CIMA Profiles - Newcastle University

CIMA is led by the Centre Director, Professor Malcolm Jackson, in collaboration with Site Directors Professor Eugene McCloskey and Professor John Loughlin. To view the profiles of our Directors, Co-Investigators, Research Collaborators and Students at each site, please click on the 'View Profiles' buttons at the bottom of this page.


Collaborators

Dr Fraser Birrell

Newcastle University

Dr Birrell is an Honorary Senior Clinical Lecturer in the Institute of Cellular Medicine, and is part of the Musculoskeletal Research Group in Newcastle. He is the Centre's Impact and Engagement lead

Professor Michael Briggs

Newcastle University


Professor Briggs is Professor of Skeletal Genetics in the Institute of Genetic Medicine.

Research interests: During endochondral bone growth, chondrocytes in the growth plate undergo a highly coordinated and tightly controlled process of proliferation, hypertrophy and finally apoptosis at the vascular invasion front. Chondrocyte proliferation and hypertrophy is vital for correct long bone growth, whilst apoptosis of terminal hypertrophic chondrocytes plays a critical role in the transition from chondrogenesis to osteogenesis. Disruptions to these processes lead to growth plate dysplasia and result in a heterogeneous group of genetic diseases known as skeletal dysplasias that are characterised predominantly by short-limb dwarfism.

Professor Michael Briggs

CIMA PhD Student

Ms Rebecca Brown

Newcastle University

CIMA PhD Studentship: Impact of physical activity and vitamin D supplementation in obese older adults with musculoskeletal pain; a cross-sectional study and randomised control trial

PhD supervisors: Professor John Mathers (Newcastle), Dr Nicola Hobbs (Newcastle), and Dr Daniel Cuthbertson (Liverpool)

Research interests: ageing, chemokines and inflammation

Collaborators

Dr Hyang-Min Byun

Newcastle University

Dr Hyang-Min Byun is a Newcastle University Research Fellow in the Institute of Cellular Medicine. 

Research interests: epigenetic epidemiology, effects of diet on human health through DNA methylation changes

CIMA PhD Student

Ms Kathleen Cheung

Newcastle University

Kathleen completed the CIMA MRes in Musculoskeletal Ageing in 2014.

PhD project: Epigenetic regulation of stem cell differentiation to musculoskeletal tissue

PhD supervisors: Dr David Young (Newcastle), Professor Peter Clegg (Liverpool), and Dr Carole Proctor (Newcastle)

Collaborators

Ms Alison Clapp

Newcastle University

Ms Clapp is e-Learning Teaching Fellow in the Centre for  Ageing and Vitality. Ms Clapp is Module Coordinator for the Biology of Ageing Module, delivered as part of the CIMA MRes in Musculoskeletal Ageing.

CIMA PhD Student

Mr Raul Fulea

Newcastle University

PhD project: Investigation of the effect of age-related methylation changes within enhancer regions on target gene expression using CRISPR-Ca9 technology 

PhD supervisors: Dr Louise Reynard (Newcastle), Professor David Young (Newcastle), Professor George Bou-Gharios (Liverpool)

Ms Angela Habgood

Newcastle University

CIMA PhD Studentship: The effect of cartilage-dependent matriptase activity on remodelling events in cartilage and bone in health and disease

PhD supervisors: Professor Drew Rowan (Newcastle), Professor Alison Gartland (Sheffield) and Dr Mark Birch (Newcastle)

Collaborators

Dr Thomas Hill

Newcastle University

Dr Hill is Senior Lecturer at the Human Nutrition Research Centre.

CIMA PhD Studentship Co-Supervisor: 'The effect of age and body weight in vitamin D metabolism.'

Research Interests: Nutrition and musculoskeletal health, micronutrients and health, vitamin D

Dr Thomas Hill

CIMA PhD Student

Mr David Hodgson

Newcastle University

David completed the CIMA MRes in Musculoskeletal Ageing in 2014.

PhD project: Examining the effects of G protein-coupled receptors and inflammatory signalling pathways on cartilage homeostasis using a systems biology approach

PhD supervisors: Dr Carole Proctor (Newcastle), Professor Drew Rowan (Newcastle) and Professor Francesco Falciani (Liverpool).


Collaborators

Professor Carol Jagger

Newcastle University

Professor Jagger is AXA Professor of Epidemiology of Ageing at the Institute for Ageing and Health.

Research interests: demography and epidemiology of ageing with a focus on late life functioning, both physical and mental, and including measurement as well as determinants and consequences for care.

Professor Carol Jagger

Dr Djordje Jakovljevic

Newcastle University


Dr Jakovljevic is Senior Lecturer (Research) in Cardiovascular Ageing and Heart Failure in the Cardiovascular Research Centre. 

Research interests: The growing ageing population represents one of the greatest societal challenges of our times. Identifying strategies to improve cardiovascular function is a key determinant of successful ageing because the age-related cardiovascular dysfunction and associated heart disease is the leading cause of morbidity and mortality in older people. Physical activity, exercise and associated high level of cardiorespiratory fitness reduce all-cause and cardiovascular mortality across the lifespan but their effect on cardiovascular function and underpinning molecular and cellular mechanisms in later life is not well understood.

My research aims to discover an intervention that will help people maintain and improve their cardiovascular function in older age. In short-term I will define physiological, molecular and cellular basis underpinning cardiovascular changes with ageing and exercise. I am particularly interested to investigate malleability of age-related changes in mitochondria function and inflammation with exercise in cardiac and vascular tissues and how this impact on overall cardiovascular function. In long-term, in collaboration with my colleagues from basic, applied and clinical sciences we will develop a unique intervention combining both physiological (physical activity and diet) and pharmacological therapies to improve cardiovascular function and extend healthy lifespan. We will be working with our study participants, general public and clinicians to design clinical pathways and implement large scale interventions to improve cardiovascular function in older people. This research will provide evidence to delay the onset of age-related cardiovascular diseases and provide new therapeutic targets for improving cardiovascular and overall health of our ageing society. 

Dr Djordje Jakovljevic

Co-Investigators

Emeritus Professor Tom Kirkwood

Newcastle University

Biography: Tom Kirkwood is Professor Emeritus at Newcastle University (where he was Professor of Medicine), and was Director of the Institute for Ageing and Health (2004–2011), and Scientific Director of the NIHR Biomedical Research Centre on Ageing (from 2008). In October 2011, he took up a new position as Associate Dean for Ageing, in order to provide strategic leadership for the University’s over-arching priority theme on ageing. Educated in biology and mathematics at Cambridge and Oxford, he worked at the National Institute for Medical Research, where he formed and led a new research division, until in 1993 he became the UK’s first Professor of Biological Gerontology at the University of Manchester.

Research: Tom Kirkwood’s research aims to understand the basic science of ageing including how genes as well as non-genetic factors, such as nutrition, influence longevity and health in old age. He led the first studies to demonstrate how intrinsic ageing affects the functions of tissue stem cells, pioneered the development of systems-biology approaches to ageing (including forming in 2005 the BBSRC-funded Centre for Integrative Systems Biology of Ageing and Nutrition), and has studied population aspects of ageing including evolutionary and epidemiological research aimed at linking underlying mechanisms to the impacts of ageing at the population level. He was Principal Investigator for the MRC-funded Newcastle 85+ Study, a prospective cohort study of biological clinical and psychosocial factors underlying healthy ageing in a cohort of more than 1000 participants born in 1921. He has been European President (Biology) of the International Association of Gerontology, chaired the UK Foresight Task Force on ‘Healthcare and Older People’, led the Foresight project on ‘Mental Capital Through Life’, was Specialist Adviser to the House of Lords Science & Technology Select Committee inquiry into ‘scientific aspects of ageing’ and has served on the Councils of BBSRC and the Academy of Medical Sciences. He has been Editor of Mechanisms of Ageing and Development and served on the editorial boards of a number of other journals. He has published more than 300 scientific papers and won several international prizes for his research. His books include the award-winning ‘Time of Our Lives: The Science of Human Ageing’, ‘Chance, Development and Ageing’ (with Caleb Finch) and ‘The End of Age’ based on his BBC Reith Lectures in 2001. 

Emeritus Professor Tom Kirkwood

Collaborators

Dr Viktor Korolchuk

Newcastle University


Dr Korolchuk is Reader in Molecular Cell Biology in the Ageing Research Laboratories, Institute for Cell and Molecular Biosciences

CIMA PhD Studentship Co-Supervisor: 'Systems modelling to maintain redox homeostasis in ageing skeletal muscle.'

Research interests: Macroautophagy, for simplicity frequently called autophagy, is a mechanism used by cells to survive periods of starvation by degrading cytoplasmic components and releasing much-needed metabolites and energy. Autophagy is a vesicular trafficking pathway in which double-membraned intracellular structures called autophagosomes are formed around portions of cytoplasm containing cellular components destined for degradation. Autophagosomes are transported along microtubules and their lives end when they fuse with lysosomes, where autophagic substrates are degraded. The process of autophagosome formation and maturation is under tight control and is orchestrated by dedicated machinery.

Both basal and induced autophagy is an important determinant of health and longevity. Indeed, perturbations in the autophagy pathway have been recognised as a causative factor in a number of human pathologies including cancer, heart diseases, diabetes and neurodegeneration. Moreover, the ageing itself, being the most important risk factor in the development of many human diseases, has been associated with insufficient clearance of misfolded, toxic and aggregate-prone proteins via the autophagosome- and lysosome-dependent degradation mechanisms. Most excitingly, many of the treatments prolonging lifespan in model organisms are doing so in an autophagy-dependent manner indicating that efficient protein degradation via autophagy may be the major determinant of lifespan extension. 

Dr Viktor Korolchuk

Directors

Professor John Loughlin

Newcastle University

Biography: Professor Loughlin is a molecular and cell biologist with a background in genetics. His first degree was in applied biochemistry at Liverpool John Moores University followed by a PhD in developmental biology at the University of Leeds. His postdoctoral studies were undertaken in the group of Professor Bryan Sykes at the Institute of Molecular Medicine at the University of Oxford. These involved a molecular genetic analysis of diseases of the musculoskeletal system. He subsequently obtained a fellowship from the Arthritis Research Campaign (now known as Arthritis Research UK) and established a group at the Wellcome Trust Centre for Human Genetics. At that point his focus became the genetic analysis of osteoarthritis (OA). In 2002 he was awarded a tenured lectureship at Oxford and in 2008 moved to Newcastle as Professor of Musculoskeletal Research. Professor Loughlin is Professor of Musculoskeletal Research in the Institute of Cellular Medicine. 

Research: My group's principal research focus is identifying and then characterising those genes that confer risk towards the development and progression of osteoarthritis. Osteoarthritis (OA) is a common disease involving loss of normal joint function. It is painful, debilitating and impacts not only on the quality of life but also on the length of life (http://www.arthritisresearchuk.org/arthritis-information/conditions/osteoarthritis.aspx).The form of the disease that we mostly work on is the one that arises without an obvious cause, such as in the absence of a clear injury. This form of OA, known as primary OA, affects older people.

A number of epidemiological studies have demonstrated that OA has a large genetic component. Through the application of powerful genome-wide association scans involving tens of thousands of OA patients we have identified a number genes harbouring susceptibility alleles for OA. Our efforts are directed toward comprehensive functional analysis of the risk alleles within these genes and in others that are emerging from ongoing scans (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575889).

Professor John Loughlin

Co-Investigators

Professor John Mathers

Newcastle University

Biography: Professor Mathers graduated with a BSc in Agricultural Biochemistry and Nutrition from Newcastle University in 1971. He was awarded a Diploma in Nutrition (with Distinction) from University of Cambridge in 1973 and PhD from University of Cambridge in 1979. Professor Mathers undertook post-doctoral training in the Department of Applied Biology in the University of Cambridge and in the Department of Tropical Animal Health, University of Edinburgh. In 1983 he was appointed as Lecturer in Human Nutrition in Newcastle University. In 1994, he established the Human Nutrition Research Centre, Newcastle University and was appointed Professor of Human Nutrition in Newcastle University in 1995. 

Research interests: John’s major research interests are in understanding the role of diet in the aetiology and prevention of common age-related diseases and in the modulation of the ageing process. This research includes studies from the molecular and cellular levels to large-scale human intervention trials. He has a particular interest in diet-gene interactions. His current work includes the LiveWell Programme which is developing and piloting lifestyle-based interventions to promote healthy ageing and developing tools to measure the healthy ageing phenotype. In addition, he is using post-genomic technologies to i) develop and test biomarkers of bowel cancer risk which are modifiable by dietary factors, ii) investigate of the effect of nutrient supply in utero on health in later life with a particular focus on the role of epigenetic mechanisms and iii) develop novel biomarkers of dietary exposure using metabolomics approaches. 

Professor Mathers’ research is funded by the MRC through the LifeLong Health and Wellbeing initiative, the BBSRC and the EU.

Professor John Mathers

CIMA PhD Student

Mr Neil McDonald

Newcastle University

Neil completed the CIMA MRes in Musculoskeletal Ageing in 2014.

PhD project: Modelling the mTOR pathway to optimise the effect of dietary restriction on the musculoskeletal system

PhD supervisors: Dr Daryl Shanley (Newcastle), Professor Ilaria Bellantuono (Sheffield) and Proessor Tom Kirkwood (Newcastle)

Collaborators

Dr Nicola O'Brien (née Hobbs)

Newcastle University


Dr O'Brien is a Research Methodologist in the Institute of Health and Society.

CIMA PhD Studentship Co-Supervisor: 'Impact of physical activity and vitamin D supplementation in obese older adults with musculoskeletal pain: a cross-sectional study and randomised control trial.'

Research interests: Testing and developing behaviour change theories and interventions, using an n-of-1 (single case) methodology to test theory and interventions at the individual level, physical activity and disability behaviours in people with chronic illness, pain and pain management

Dr Nicola O

Dr João Passos

Newcastle University

Dr Passos is a Reader in Biology of Ageing at the Institute for Ageing and Institute for Cell and Molecular Biosciences.

Research interests: Molecular mechanisms involved in ageing, in particular the role of mitochondrial ROS production and its interaction with telomeres, the role of cysteine oxidation in ageing, systems biology approaches to study the ageing process.

Dr Arthur Pratt

Newcastle University

Dr Pratt is Intermediate Clinical Fellow at the Institute of  Cellular Medicine and and Honorary Consultant Rheumatologist  at the Freeman Hospital. 

Research interests: I am interested in how an improved understanding of the aetiopathogenesis of early rheumatoid arthritis (RA) might improve our ability to diagnose and treat patients with the disease. My research seeks to identify molecular biomarkers that begin to stratify this highly heterogeneous condition into subgroups of clinical significance.

Dr Carole Proctor

Newcastle University

Dr Proctor is a Lecturer in the Institute of Cellular Medicine and Institute for Ageing and Programme Director for the CIMA MRes in Musculoskeletal Ageing at Newcastle University.

CIMA PhD Studentship Primary Supervisor: 'Examining the effects of G protein-coupled receptors and inflammatory signalling pathways on cartilage homeostasis using a systems biology approach.'

CIMA PhD Studentship Co-Supervisor: 'Epigenetic regulation of stem cell differentiation to musculoskeletal tissues.'

CIMA PhD Studentship Co-Supervisor: Systems modelling to maintain redox homeostasis in ageing skeletal muscle.'

Research interests: Modelling the molecular mechanisms of ageing such as telomere shortening and uncapping; DNA damage checkpoint response pathways; cell signalling pathways; and the role of chaperones and protein degradation pathways in maintaining protein homeostasis; and the decline of these systems with age. I have extensively modelled the mechanisms and pathways involved in the decline in protein homeostasis and how this leads to the aggregation of proteins. 

Dr Louise Reynard

Newcastle University

Dr Reynard is a Lecturer in the Institute of Cellular Medicine. 

CIMA PhD Studentship Co-Supervisor: 'How does glucose modulate age-related epigenetic alterations in musculoskeletal tissues?' 

CIMA PhD Studentship Co-Supervisor: 'An examination using murine models of the epigenetic changes that occur with age in bone marrow mesenchymal stem cells.'

Research interests: Dr Reynard’s research is focused on the functional characterisation of osteoarthritis (OA) susceptibility loci that have been identified by the arcOGEN consortium. Elucidating the molecular mechanisms that underlie the susceptibility mediated by these genes will increase our understanding of OA etiology, potentially aid diagnosis and treatment, and will suggest relevant targets for therapeutic investigation. Louise is also interested in the molecular interplay between genetics and epigenetics in OA susceptibility, in particular, how DNA methylation can modulate the effect of genetic variation on disease penetrance and severity. She is currently looking at the effect DNA methylation has on the expression of the OA susceptibility gene GDF5 in different synovial joint tissues.

Professor Lynn Rochester

Newcastle University


Professor Rochester is Professor of Movement Science in the Institute of Neuroscience and the Institute for Ageing and Health.

CIMA PhD Studentship Co-Supervisor: 'Analysis of the upper body movements during gait for the assessment of locormotor ability.'

Research Interests: My research interests are concerned with motor control of gait, motor learning, the complex interactions of motor and non-motor symptoms, and their consequences for independent mobility in the older person. I lead a research programme entitled 'Gait and Activity in Ageing and Disease' with a particular focus on the interaction between cognitive and motor functions in age and neurodegenerative disease.

Professor Lynn Rochester

Professor Drew Rowan

Newcastle University


Professor Rowan is Professor of Molecular Rheumatology in the Institute of Cellular Medicine.

CIMA PhD Studentship Primary Supervisor: 'The effect of cartilage-dependent matriptase activity on remodelling events in cartilage and bone in health and disease,'

CIMA PhD Studentship Co-Supervisor: 'Examining the effects of G protein-coupled receptors and inflammatory signalling pathways on cartilage homeostasis using a systems biology approach.'

Research Interests: I am a proteinase biochemist with an interest in the molecular mechanisms that regulate enzymic activity and the transcriptional control of proteinase genes within the setting of joint diseases such as rheumatoid and osteoarthritis.

Professor Drew Rowan

Professor Avan Sayer

Newcastle University

Professor Sayer is Professor of Geriatric Medicine and Director of the NIHR Newcastle Biomedical Research Centre (BRC).

Biography: I am Director of the NIHR Newcastle Biomedical Research Centre (BRC) and we were delighted to be awarded £16.2M for a further 5 years funding in the most recent national competition. Newcastle’s reputation for excellence in ageing research across the translational pathway combined with the opportunity to lead the BRC, considered by many to be the ‘jewel in the crown’ of NIHR research infrastructure, were key to my decision to move to Newcastle. My clinical speciality is geriatric medicine and I have international recognition in the field of Geriatrics and Gerontology for my research on ageing, sarcopenia (the age-related loss of skeletal muscle mass and function), frailty and multimorbidity. Major research contributions to date include i) discovery of early life influences on human ageing; ii) development of a life course approach to sarcopenia and frailty using clinical, epidemiological and biological approaches; and iii) innovative ageing experimental medicine to optimise health and healthcare in later life.

I was previously an MRC Principal Investigator, Programme Leader and Professor of Geriatric Medicine at the MRC Lifecourse Epidemiology Unit, University of Southampton, where I now hold a Visiting Professor position. Other current roles include Secretary to the UK Association of Academic Geriatric Medicine, Member of the Academic Board of the European Union Geriatric Medicine Society, Associate Editor at Age and Ageing and recently Raine Visiting Professor at the University of Western Australia. I serve on a number of UK and international advisory committees and expert panels.

Research: The three main aims of the BRC are: to drive innovation in the prevention, diagnosis and treatment of ill-health through early translational (experimental medicine) research; to translate advances in biomedical research into benefits for patients, the health system and for broader economic gain; and to provide a key component of the NHS contribution to national and international competitiveness. So we are now perfectly positioned to exploit Newcastle’s established track record in experimental medicine and apply it to optimising health and healthcare in ageing and long-term conditions. A particular focus will be sustainable capacity building in ageing experimental medicine in the North East and wider, building on my track record of setting up a flourishing NIHR integrated academic training programme in geriatric medicine and leading an innovative interdisciplinary gerontology group in Southampton prior to moving to Newcastle.

Dr Daryl Shanley

Newcastle University

Dr Shanley is a Senior Lecturer in the Institute for Ageing and Health, and Director of the Centre for Integrative Systems Biology of Ageing and Nutrition (CISBAN). 

CIMA PhD Studentship Primary Supervisor: 'Systems modelling to maintain redox homeostasis in ageing skeletal muscle.'

CIMA PhD Studentship Primary Supervisor: 'Modelling the mTOR pathway to optimise the effect of dietary restriction on the musculoskeletal system.'

Research interests: I have spent several years developing mathematical models that examine ageing as an integral part of an optimal life history. One of my main aims is to gain a more in-depth understanding of the ageing process by building models with a solid mechanistic base and making them available for use by others.

Dr Mario Siervo

Newcastle University


Dr Siervo is a Clinical Scientist and Lecturer in Nutrition and Ageing in the Institute for Ageing and Health.

Research Interests: Nutrition, endothelial function and chronic metabolic diseases.

Professor Falko Sniehotta

Newcastle University


Professor Sniehotta is a Professor in Behaviour Medicine and Health Psychology in the Institute of Health and Society.

Research Interests: My research programme aims to develop and test: a) theory of behaviour change and b) interventions to change behaviours relevant to health and health care. I am passionate about contributing to the development of an evidence-based science of behaviour change. My research covers a range of behaviours of patients, members of the public and health care professionals and a range of methodologies including randomised controlled trials, systematic reviews, experiments, predictive studies and n-of-1 studies. Much of my empirical work is conducted in interdisciplinary collaboration and I have a particular focus on capacity development and training. 

Professor Falko Sniehotta

Professor Emma Stevenson

Newcastle University

Professor Stevenson is Professor of Sport and Exercise Science at the Institute of Cellular Medicine. 

Research interests: t

he role of nutritional interventions in exercise recovery, e


xercise, nutrition and postprandial glycaemic control, p


rotein, exercise and appetite regulation with a particular focus on dairy proteins, n


utrition, exercise and and healthy ageing.

Professor Michael Trenell

Newcastle University


Professor Trenell is a Clinical Scientist, Director of the UK National Institute for Health Research Innovation Observatory National Institute for Health Research, former NIHR Senior Fellow and former Diabetes UK RD Lawrence Fellow

CIMA PhD studentship Co-Supervisor: 'Are older people at increased risk of adverse physiological consequences of sedentary behaviour?'

Research interests: My core research projects look at how metabolism can be improved in a number of different metabolic disorders. A significant focus of my research is on how increased physical activity and exercise can be used as a clinical therapy in metabolic disorders (Type 2 diabetes and non-alcoholic fatty liver disease), neuromuscular disease, ageing and in promoting lifelong health and wellbeing.

Professor Michael  Trenell

Professor Sir Doug Turnbull

Newcastle University

Professor Sir Doug Turnbull is Professor of Neurology and Director of the Institute for Ageing and Health and Director of the Wellcome Trust Centre for Mitochondrial Research

Research interests: Professor Sir Doug Turnbull's major research interest is the role of mitochondrial DNA mutations in disease, exploring the role of mitochondrial abnormalities in neurodegenerative disease, ageing and cancer.

Professor Sir Doug Turnbull

Professor Thomas von Zglinicki

Newcastle University



Professor von Zglinicki is Professor of Cellular Gerontology in the Institute for Ageing and Health.

Research interests: Telomeres appear to be a key to switch human cells between mortality and immortality.  Telomere shortening eventually triggers the check point mechanisms leading to replicative senescence, while maintenance of telomeres, for instance by active telomerase, allows unrestricted growth.  We have shown that a major reason for the shortening of telomeres (in addition to a minor contribution from the end-replication problem) is oxidative damage, combining for the first time the free radical theory of ageing with the telomere hypothesis of cellular senescence (von Zglinicki et al 1995, von Zglinicki et al 2000).  In comparison to the rest of the genome, telomeres are somewhat deficient in single-strand break (base excision) repair (Petersen et al 1998), resulting in telomere-specific accumulation of damage in non-dividing cells, which in turn hinders complete replication of telomeres, leading to telomere shortening during DNA replication (Sitte et al 1998, von Zglinicki 2000).  We demonstrated that free single-stranded G-rich telomeric DNA (free overhangs) are potent trigger for a p53-dependent, senescence-like cell cycle arrest (Saretzki et al 1999).  In addition, we were interested in inhibition of telomerase in tumor cells (Mueller et al 1998) and in the role of protein turnover and lipofuscin accumulation during replicative senescence and postmitotic ageing (Sitte et al 2000a, b).

Cellular ageing and telomere maintenance: Accelerated telomere shortening due to increased oxidative stress results in premature ageing of normal cells, while senescence can be delayed if the telomere shortening rate is decreased by increasing the cell's antioxidative capacity.  Telomerase activation occurs most probable at crisis, and can result in immortal growth.

Professor David Young

Newcastle University


Professor Young is Professor of Musculoskeletal Biology in the Institute of Genetic Medicine.

CIMA PhD Studentship Primary Supervisor: 'Epigenetic regulation of stem cell differentiation to muscuolskeletal tissue,'

CIMA PhD Studentship Co-Supervisor: 'Inflamm-ageing and tissue homeostasis: how does inflammatory mediator TGFβ regulate the synthesis of degradation-resistant type 1 collagen (l).'

Research Interests: My research interests include the expression and regulation of metalloproteinases (MPs) and their inhibitors the TIMPs, particularly in the context of osteoarthritis (OA). My laboratory focus is how these genes are epigenetically regulated; by microRNAs, DNA methylation and chromatin modifications. We are also investigating the role of mitochondria and the role of ubiquitination in OA.

Main techniques: Gene expression analysis/profiling (Real-time PCR, Taqman Low density arrays, microarray, RNA-seq). Cell signalling analysis. RNAi (siRNA, shRNA). miRNA analysis. Transcription factor analysis (EMSA, mutagenesis, reporter assays). Epigenetic analysis.

Professor David Young