Innovation from the beginning

The MRC-Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing (CIMA) was formed in 2012 and has developed an integrated approach to studying the effects of ageing on the musculoskeletal system, which has been demonstrably successful.

We have focused our activities in areas of critical mass where collaborations have provided enhanced value. These include the role of epigenetic changes in cells and tissues affected by musculoskeletal ageing, the development of an assessment protocol for monitoring age-related decline in the musculoskeletal system (the CIMA Toolkit), and proof of principle pre-clinical and human studies to identify interventions that reduce the deleterious effects of ageing on the musculoskeletal system. We have developed an innovative graduate training programme and undertaken well-received public engagement activities.


Our first five years in numbers


3 Collaborating universities

7 work packages

24 new academic posts

19 cohort databases established

2 partner funders

13 scientific MEETINGS held

3 clinical fellows trained

8973 enrolments in our mooc

5 years so far

more than 600 publications


18 PhD students


over £40m awarded to cima researchers